Khushmatov Sh.S.¹ , Omonturdiev S.Z.² , Eshbakova K.A.¹ , Usmanov P.B.² , Toshmatov Z.O.¹

1 A.S.Sadikov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, 100125, Tashkent, Uzbekistan
2 S.Yu.Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Tashkent, Uzbekistan
Author    Correspondence author
Medicinal Plant Research, 2012, Vol. 2, No. 5   doi: 10.5376/mpr.2012.02.0005
Received: 18 Oct., 2012    Accepted: 22 Oct., 2012    Published: 27 Nov., 2012

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Khushmatov et al., 2012, Relaxant Effect of the Flavonoid Pulicarin, Medicinal Plant Research, Vol.2, No.5 21-25 (doi: 10.5376/mpr.2012.02.0005)

It was established that the relaxant effect of flavonoid pulicarin in conditions of phenylephrine and KCl- induced contraction was related to the inhibition of the influx of Ca²⁺ ions through the receptor-operated and potential-dependent Ca²⁺-channels of smooth muscle cell (SMC). The relaxant effect of pulicarin was revealed to be endothelium dependent and caused by the activation of NO/guanylate cyclase system.

Flovonoid; Smooth muscle cells; Contraction activity; Membrane ion channels; Receptors