Relaxant Effect of the Flovonoid Pulicarin
1 A.S.Sadikov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, 100125, Tashkent, Uzbekistan
2 S.Yu.Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Tashkent, Uzbekistan
Medicinal Plant Research, 2012, Vol. 2, No. 5 doi: 10.5376/mpr.2012.02.0005
Received: 18 Oct., 2012 Accepted: 22 Oct., 2012 Published: 27 Nov., 2012
© 2012 BioPublisher Publishing Platform
This is an open access article published under the terms of the Creative Commons Attribution License
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:
Khushmatov et al., 2012, Relaxant Effect of the Flavonoid Pulicarin, Medicinal Plant Research, Vol.2, No.5 21-25 (doi: 10.5376/mpr.2012.02.0005)
It was established that the relaxant effect of flavonoid pulicarin in conditions of phenylephrine and KCl- induced contraction was related to the inhibition of the influx of Ca2+ ions through the receptor-operated and potential-dependent Ca2+-channels of smooth muscle cell (SMC). The relaxant effect of pulicarin was revealed to be endothelium dependent and caused by the activation of NO/guanylate cyclase system.
Flovonoid; Smooth muscle cells; Contraction activity; Membrane ion channels; Receptors