Evaluation effect of Hydroalcoholic Extract of Eucalyptus globulus and Artemisia draconculus compare with acyclovir against Herpes Simplex Virus Type 1  

Aghaei afshar Davood1 , Zahedi Mohammad javad2 , Arabzadeh Alimohammad2 , Aghaei afshar Abbas2 , Mollaei Hamidreza2
1. Chamran university, Kerman, Iran
2. Kerman University of Medical Sciences, Kerman, Iran
associate professor of Kerman university of medical sciences,Iran
assistant professor of kerman university of medical sciences
phd student of medical sciences
Author    Correspondence author
Medicinal Plant Research, 2012, Vol. 2, No. 2   doi: 10.5376/mpr.2012.02.0002
Received: 10 Jul., 2012    Accepted: 18 Jul., 2012    Published: 23 Jul., 2012
© 2012 BioPublisher Publishing Platform
This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

 Davood et al., 2012, Evaluation Effect of Hydroalcoholic Extract of Eucalyptus globulus and Artemisia draconculus Compare with Acyclovir Against Herpes Simplex Virus Type 1, Medicinal Plant Research, Vol.2, No.2 6-10 (doi: 10.5376/mpr.2012. 02.0002)


Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as Human herpes virus 1 and 2 are two members of the herpes virus family, Herpesviridae, that infect humans. Both HSV-1 (which produces most cold sores) and HSV-2 (which produces most genital herpes) are ubiquitous and contagious. They can be spread when an infected person is producing and shedding the virus. The present study was carried out to determine the effect of alcoholic extract of two herbs Eucalyptus globulus and Artemisia draconculus on herpes virus compare with acyclovir in Iran during 2011. After preliminary survey, two herbs Eucalyptus globulus and Artemisia draconculus were selected as a drug for the treatment of herpes virus. HSV-1 was isolated from patients and identified by specific monoclonal antibodies. Vero cells (African green monkey kidney cells) were cultured with Dulbecco’s Modified Eagles’ Medium (DMEM) supplemented with 10% heat inactivated Fetal Bovine Serum (FBS), 100 IV/mL penicillin and l μg/mL streptomycin. Finally, the effect of these plants and Acyclovir compared with together on herpes virus. Results showed Artemisia draconculus could not reduce viral plaques significantly, however methanolic extracts of Eucalyptus globulus had a significant inhibitory effect against HSV-1 and concentration (200, 150, 50 μg/mL) has the best effect and (>200 μg/mL) Has lowest effect on HSV-1.The comparison of results exhibited that Eucalyptus globulus extract has more effects in different dilutions against HSV-1 in cell culture.

Herpes virus; Eucalyptus globulus; Artemisia draconculus; Acyclovir
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