Haiyan Chen^1,2 , Si Chen³ , Jinge Zhang¹ , Yan Yang⁴ , Yanran Wang¹ , Yaning Zhang¹ , Haijie Xu¹ , Jiying Liu¹ , Dianda Zhang¹

1 College of Life Sciences, Changchun Sci-Tech University, Changchun, 130600, Jilin, China
2 College of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130117, Jilin, China
3 Yanbian Yida Birch Industry Co., Ltd., Changchun, 132000, Jilin, China
4 Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Fengxian, 201403, Shanghai, China
Author    Correspondence author
Medicinal Plant Research, 2024, Vol. 14, No. 5   doi: 10.5376/mpr.2024.14.0022
Received: 20 Aug., 2024    Accepted: 28 Sep., 2024    Published: 12 Oct., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Chen H.Y., Chen S., Zhang J.G., Yang Y., Wang Y.R., Zhang Y.N., Xu H.J., Liu J.Y., and Zhang D.A. 2024, Pharmacological effects of Sanghuangporus spp. extract and its application in the prevention and treatment of chronic diseases, Medicinal Plant Research, 14(5): 259-274 (doi: 10.5376/mpr.2024.14.0022)

Sanghuangporus spp., a traditional medicinal fungus, has garnered significant scientific attention due to its diverse pharmacological properties. This study systematically explores the bioactive components of Sanghuangporus spp., such as polysaccharides, triterpenoids, and flavonoids, and their mechanisms of action in preventing and treating various chronic diseases. Sanghuangporus spp. exhibits potent antioxidant, anti-tumor, anti-inflammatory, immunomodulatory, hepatoprotective, anti-diabetic, and cardiovascular protective effects. These characteristics make it a promising natural remedy for managing chronic conditions such as cancer, diabetes, liver disease, and cardiovascular disorders. However, challenges remain in standardizing Sanghuangporus spp. extracts, ensuring quality consistency, and translating preclinical findings into clinical practice. Future research should focus on large-scale clinical trials to elucidate the molecular mechanisms of its bioactive compounds and overcome regulatory barriers to integrate Sanghuangporus spp. into modern therapeutic strategies. This study evaluates the safety and efficacy of Sanghuangporus spp. extract, providing theoretical and practical references for its development into functional foods and pharmaceuticals.

Sanghuangporus spp.; Pharmacological effects; Chronic diseases; Antioxidant; Anti-tumor