The paper deals with 44 species of plants covering 43 genera and 31 families used for curing rheumatoid arthritis by the tribes of East Godavari district, Andhra Pradesh. Fabaceae is the dominant family with 6 species followed by Acanthaceae, Euphorbiaceae (3 species each), Asteraceae, Meliaceae, Asclepiadaceae, Lamiaceae (2 species each) and others. Herbs (15) are dominant followed by trees and shrubs (14 each) and a lone climber. Leaf is used in 12 practices followed by root (11), seed (7), stem bark (4), fruit (3) and others. Amorphophallus sylvaticus, Jatropha glandulifera, Perilla frutescens, Ruellia tuberosa and 22 practices were found to be new or less known.