Linhua Zhang ¹ , Guangman Xu²

1 Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, Zhejiang, China
2 Traditional Chinese Medicine Research Center, Cuixi Academy of Biotechnology, Zhuji, 311800, Zhejiang, China
Author    Correspondence author
Medicinal Plant Research, 2025, Vol. 15, No. 5   doi: 10.5376/mpr.2025.15.0023
Received: 05 Aug., 2025    Accepted: 25 Sep., 2025    Published: 19 Oct., 2025

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Zhang L.H., and Xu G.M., 2025, Multi-target pathways of Angelica sinensis in cardiovascular and cerebrovascular protection, Medicinal Plant Research, 15(5): 214-223 (doi: 10.5376/mpr.2025.15.0023)

Angelica sinensis is a commonly used ingredient in traditional Chinese medicine. Its main function is to promote blood circulation and replenish blood. It is also widely used in regulating the functions of the cardiovascular and cerebrovascular systems. This study focuses on its multi-target mechanism of action in cardiovascular and cerebrovascular diseases, especially the active components, liek polysaccharides, ligustilide and ferulic acid. Research has found that, A. sinensis can exert anti-inflammatory, antioxidant, anti-apoptotic and neural repair effects through pathways, such as PI3K/Akt, MAPK, Nrf2/HO-1, etc., alleviate the damage caused by myocardial and cerebral ischemia-reperfusion, and also enhance vascular endothelial function and the stability of the blood-brain barrier. Animal and cell experiments also suggest that, it can regulate blood lipids, improve the microenvironment and delay aging. Although there is currently a lack of large-scale clinical validation, the existing research foundation provides reliable support for its development into a standardized plant-based drug.

Angelica sinensis; Cardiovascular and cerebrovascular protection; Multi-target mechanism; Antioxidant; Anti-inflammatory; Signal path