Zhichao Chen ¹ , Haijuan Zhang ²

1 Department of Traditional Chinese Medicine, Longquan People’s Hospital, Longquan, Zhejiang, 323000, China
2 Longquan Agricultural and Rural Bureau, Longquan, Zhejiang, 323700, China
Author    Correspondence author
Medicinal Plant Research, 2025, Vol. 15, No. 1   doi: 10.5376/mpr.2025.15.0001
Received: 08 Dec., 2024    Accepted: 10 Jan., 2025    Published: 21 Jan., 2025

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Chen Z.C., and Zhang H.J., 2025, The interaction between Ganoderma lucidum polysaccharides and gut microbiota: implications for immune health, Medicinal Plant Research, 15(1): 1-11 (doi: 10.5376/mpr.2025.15.0001)

Ganoderma lucidum polysaccharides (GLPs) are natural polysaccharide compounds extracted from Ganoderma lucidum, known for their diverse biological activities. This study explores the interaction between GLPs and gut microbiota and its effects on immune health, revealing how GLPs regulate immune responses through gut microbiota and investigating their potential applications in preventing and treating immune-related diseases. The study shows that GLPs can increase the production of short-chain fatty acids, regulate the proportion of beneficial gut bacteria, and alleviate inflammatory responses by modulating the TLR4/MyD88/NF-κB signaling pathway. The results indicate that GLPs significantly improve gut microbiota imbalance, enhance macrophage phagocytosis, and increase the cytotoxicity of natural killer cells, demonstrating their potential in immune regulation and disease prevention. Future research will focus on further uncovering the molecular mechanisms of GLPs and their long-term application potential in human health.

Ganoderma lucidum polysaccharides; Gut microbiota; Immune health; Interaction; Disease prevention